By Ramesh N. Patel
Written through across the world well-known scientists in biocatalysis, the authors learn the synthesis of chiral intermediates for over 60 brand-name prescribed drugs for a variety of drug treatments and coverings. From beginning fabric to product, the chapters supply precise mechanisms that exhibit chiral intermediates and different by-products for every reaction—including hydrolytic, acylation, halogenation, esterification, dehalogenation, oxidation-reduction, oxygenation, hydroxylation, deamination, transamination, and C–C, C–N, C–O bonds formation. state-of-the-art issues comprise complicated methodologies for gene shuffling and directed evolution of biocatalysts; the customized engineering of enzymes; using microbial cells and remoted biocatalysts; using renewable beginning fabrics; and producing novel molecules by way of combinatorial biocatalysis and high-throughput screening.
Focusing on commercial purposes, the ebook additionally considers components reminiscent of bulk techniques, instrumentation, solvent choice, and strategies for catalyst immobilization, reusability, and yield optimization all through. Biocatalysis within the Pharmaceutical and Biotechnology Industries showcases the sensible benefits and methodologies for utilizing biocatalysts to strengthen and convey chiral prescription drugs and high quality chemicals.
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Biocatalysis in the Pharmaceutical and Biotechnology Industries by Ramesh N. Patel