Get Biotransformation and Metabolite Elucidation of Xenobiotics: PDF

By Ala F. Nassar

ISBN-10: 0470504781

ISBN-13: 9780470504789

The aim of this ebook is to enhance the readers' wisdom of metabolite elucidation in drug metabolism through exposing them to intensive assurance of the biotransformation of xenobiotics, recommendations for deciding on and characterizing metabolites, FDA directions, and case experiences on the right way to enhance the decision-making procedure in structural amendment of drug applicants to lessen toxicity.

The publication includes eight chapters; it first presents an creation on biotransformation of xenobiotics, after which offers smooth methods and techniques for facing metabolite characterization, utilizing instruments akin to LC-MS, H-D trade, strong isotopes LC-MS-NMR, and radiolabeled compounds. additionally, concepts for facing reactive intermediates in drug discovery and improvement are awarded in addition to case reports on enhancing the decision-making method within the structural amendment of drug applicants. The final bankruptcy discusses the regulatory views of defense checking out of drug metabolites and why, how, and whilst to check their safety.

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Biotransformation and Metabolite Elucidation of Xenobiotics: Characterization and Identification by Ala F. Nassar


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