By Ala F. Nassar
The publication includes eight chapters; it first presents an creation on biotransformation of xenobiotics, after which offers smooth methods and techniques for facing metabolite characterization, utilizing instruments akin to LC-MS, H-D trade, strong isotopes LC-MS-NMR, and radiolabeled compounds. additionally, concepts for facing reactive intermediates in drug discovery and improvement are awarded in addition to case reports on enhancing the decision-making method within the structural amendment of drug applicants. The final bankruptcy discusses the regulatory views of defense checking out of drug metabolites and why, how, and whilst to check their safety.
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Biotransformation and Metabolite Elucidation of Xenobiotics: Characterization and Identification by Ala F. Nassar